Periodontitis genetic

How To Prevent This Gum Disease. Find Your Toothpaste Today! The concept of a cellular basis for genetic susceptibility to adult periodontitis also has been subjected to laboratory investigation by means of the in-vitro twin paradigm. Genetic factors which could modify the risk of a person developing periodontitis include: Defects of Phagocytosis : person may have hypo-responsive phagocytes.

Hyper-production of interleukins , prostaglandins and cytokine s. Current studies suggest that periodontal disease is influenced by heredity, so your genetic makeup truly does have the potential to make you more susceptible to periodontitis.

In some cases it can affect all of the teeth. Figures and table: role of genetics in periodontitis While genetic factors are known to play a role in periodontitis, a lot of research still needs to be done to understand the precise mechanisms involved. Studies were conducted using different methods in the evaluation of genetic predisposition to periodontitis. Periodontitis is considered a complex disease where a particular gene is not associated with the disease.

The genetic component plays a key role in the onset of PD. In fact the genetic compound can modulate the inflammation of the mucous membranes and the loss of alveolar bone. A study in the Journal of Medical Genetics indicated that gum disease could be a genetic predisposition.

Researchers discovered that changes in a gene for the enzyme Cathepsin-C are responsible for a condition known as Papillon-Lefevre syndrome.

Along with scaly and warty skin thickening and an erosion. The complex pathogenesis of periodontitis implies the involvement of a susceptible host and a bacterial challenge. A groundbreaking study found that children of parents with periodontitis are times more likely to have the bacteria associated with the progression of gum disease.

Through recent leaps in testing technology, hereditary ( genetic ) susceptibility toward developing severe gum disease can be detected. The main cause of periodontal (gum) disease is plaque, but other factors affect the health of your gums. Studies indicate that older people have the highest rates of periodontal disease. Data from the Centers for Disease Control and Prevention indicates that over of Americans and older have periodontitis. Chin, from the Academic Centre for Dentistry in Amsterdam.

Here, they outline what is known today and discuss the most promising lines of inquiry. Figure 6-Case–control design for a genetic association study. Periodontitis cases shown on the left have frequencies for a hypothetical genetic marker of AA, AC, and CC, which are substantially different from genotype frequencies found in healthy periodontal controls of AA, AC, and CC.

Periodontal (gum) disease is an infection of the tissues that hold your teeth in place. Periodontal disease is caused by bacteria in dental plaque, the sticky substance that forms on your teeth a couple of hours after you have brushed. In an effort to eliminate the bacteria,. Many studies have provided a valuable contribution to understanding the genetic basis of periodontal disease,.

Richa Sharma MDS 2nd yr Dept of Periodontology and Oral Implantology 2. Among families with consistent inheritance of a disease, linkage studies can determine the chromosomal region or genetic variant (polymorphism). It happens when bacteria and plaque build up around the tooth, and the immune system launches a reaction.

Good oral hygiene is part of both treatment and prevention, but sometimes surgery is necessary too. The plaque bacteria can infect your gums and teeth, and eventually, the gum tissue and bone that support the teeth will be impacted. It is the inflammation of the gums, caused by dental plaque buildup at the gum line. It causes the gums to become re swollen, and bleed easily.

There is usually little or no discomfort at this stage. Gingivitis is the mildest form of periodontal disease.